Blog Post #1
Note for my self:
Bardgett, Mark E et al. “Dopamine modulates effort-based decision making in rats.” Behavioral neuroscience vol. 123,2 (2009): 242-51. doi:10.1037/a0014625
Abstract:
Previous research has implicated dopamine as a modulating factor in choice behavior based on effort. The purpose of the present study was to determine the individual contribution of different dopamine receptors to effort-based decision-making in rats. Rats were trained in a T-maze to choose a large-reward arm that contained eight pellets of food over a small-reward arm that contained two pellets of food. The rats then were trained to climb progressively higher barriers in order to obtain the food from the large-reward arm. Using a discounting procedure on each test day, it was found that rats were more likely to choose the small-reward arm after treatment with the D1 antagonist, SCH-23390, or the D2 antagonist, haloperidol. The dopamine agonist, D-amphetamine, biased the rats towards choosing the large-reward arm and blunted the effects of SCH-23390 or haloperidol. Treatment with the D3 receptor antagonist, U99194, or the D3 receptor agonist, 7-OH-DPAT, did not alter choice behavior. These data indicate that D1 and D2 receptors are required for decisions based on effort.
Keywords: Dopamine receptor, choice behavior, T-maze, amphetamine, haloperidol, SCH-23390
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